Saliva Tests (TOS)
Salivary Hormones
Steroid Hormones
Androstenedione
Cortisol
DHEA
DHEA-S
Estriol
Estradiol
17-OH progesterone
Progesterone
Testosterone
 

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Tests › Saliva tests › Salivary Hormones › Steroid Hormones › DHEA-S

DHEA-S

Significance
DHEA-S is a steroid derived almost exclusively (90%) from the adrenal gland. It is the sulfated form of DHEA, and its concentration in serum is greater than that of any other steroid hormone and is about five hundred times that of DHEA. DHEA-S is not subject to diurnal variations nor changes during the menstrual cycle. This is partly due to its slow metabolic clearance as a result of binding to albumin. DHEA-S levels are highest at age 20-25 and decline with advancing years, reaching 20-30% of peak levels by age 70-80. It is a weak androgen and commonly used for assessment of adrenal androgen production. Concentrations of DHEAS are often measured, along with other hormones such as FSH, LH, prolactin, estrogen, and testosterone, to help diagnose polycystic ovarian syndrome (PCOS) and to help rule out other causes of infertility, amenorrhea, and hirsutism. This test is used also used as an aid in the evaluation of androgen excess, adrenocortical disease including congenital adrenal hyperplasia, and adrenal tumor. More recently, DHEA-S has been suggested to be a possible mediator in response to stress and perhaps a new marker of low libido in women under 45 years (rather than testosterone).

Analysis
Determination of DHEA-S is performed by Enzyme Immunoassay.

Patient Preparation
Avoid eating, brushing prior to sample collection. At time of collection, briefly rinse mouth with water and begin collection. Do not collect specimen if there is damage to gums, mouth or there are signs of bleeding where blood contamination will occur, as these will completely invalidate the test. Morning specimen is preferred. Where possible/appropriate, avoid medication that can alter levels (at least 48 hrs prior to specimen collection).

Specimen requirements
Serum specimen - from a plain redtop or a redtop gel (tiger top) tube. Separate serum from cells after centrifugation, if a plain redtop tube is used. Minimum volume required is 1 mL. Specimen should be kept refrigerated where possible.

Shipping Instructions
Ship specimen at ambient temperatures. Ensure cap on the tube is on reasonably tight to prevent leaking/spillage.

Additional information
http://www.labtestsonline.org/understanding/analytes/dheas/test.html