Serum/plasma tests
Hormones
Steroid Hormones
Androstenedione
Bioavailable testosterone
Cortisol
DHEA-S
Dihydrotestosterone (DHT) (TOS)
Estradiol
Estradiol-HRT
17-OH progesterone (TOS)
Pregnenolone
Progesterone
Testosterone
Peptide Hormones
Follicle Stimulating Hormone (FSH)
Insulin (TOS)
Luteinizing Hormone (LH)
Secretin (TOS)
Sex Hormone Binding Globulin (SHBG)
Thyroid Stimulating Hormone (TSH)
Vasoactive Intestinal Polypeptide (VIP) (TOS)
Other Hormones
Free Triiodothyronine (FT3)
Free Thyroxine (FT4)
Triiodothyronine (T3)
Thyroxine (T4)
Other

TOS - To be offered shortly


Tests › Serum/plasma tests › Hormones › Steroid Hormones › DHEA-S

DHEA-S

Significance
DHEA-S is a steroid derived almost exclusively (90%) from the adrenal gland. It is the sulfated form of DHEA, and its concentration in serum is greater than that of any other steroid hormone and is about five hundred times that of DHEA. DHEA-S is not subject to diurnal variations nor changes during the menstrual cycle. This is partly due to its slow metabolic clearance as a result of binding to albumin. DHEA-S levels are highest at age 20-25 and decline with advancing years, reaching 20-30% of peak levels by age 70-80. It is a weak androgen and commonly used for assessment of adrenal androgen production. Concentrations of DHEAS are often measured, along with other hormones such as FSH, LH, prolactin, estrogen, and testosterone, to help diagnose polycystic ovarian syndrome (PCOS) and to help rule out other causes of infertility, amenorrhea, and hirsutism. This test is used also used as an aid in the evaluation of androgen excess, adrenocortical disease including congenital adrenal hyperplasia, and adrenal tumor. More recently, DHEA-S has been suggested to be a possible mediator in response to stress and perhaps a new marker of low libido in women under 45 years (rather than testosterone).

Analysis
Determination of DHEA-S is performed by Enzyme Immunoassay.

Patient Preparation
Try to avoid medications in preparation for specimen collection (when appropriate). Glucocorticoid therapy over several days can cause a decrease in DHEA-S. Steroids, ACTH, estradiol, or gonadotropin medications can impact DHEA-S levels and should be avoided for at least 48h prior to specimen collection.

Specimen requirements
Serum specimen - from a plain redtop or a redtop gel (tiger top) tube. Separate serum from cells after centrifugation, if a plain redtop tube is used. Minimum volume required is 1 mL. Specimen should be kept refrigerated where possible.

Shipping Instructions
Ship specimen at ambient temperatures. For long distance shipping, ship with ice packs.

Additional information
http://www.labtestsonline.org/understanding/analytes/dheas/test.html